Monoclonal antibody (mAb)-based cancer therapy
نویسندگان
چکیده
Compelling evidence indicates Type I CD20 immunotherapeutic mAbs promote targeted tumor cell elimination exclusively via immune effector functions, which can be exhausted/saturated. mAb dosing paradigms should therefore take into account the capacity of these cytotoxic mechanisms, leading to the conclusion that lower doses, given frequently, may be far more effective.
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عنوان ژورنال:
دوره 1 شماره
صفحات -
تاریخ انتشار 2012